Causality assessment methods in drug induced liver injury: Strengths and weaknesses
نویسندگان
چکیده
منابع مشابه
Drug- and Herb-Induced Liver Injury in Clinical and Translational Hepatology: Causality Assessment Methods, Quo Vadis?
Drug-induced liver injury (DILI) and herb-induced liver injury (HILI) are typical diseases of clinical and translational hepatology. Their diagnosis is complex and requires an experienced clinician to translate basic science into clinical judgment and identify a valid causality algorithm. To prospectively assess causality starting on the day DILI or HILI is suspected, the best approach for phys...
متن کاملDrug-Induced Liver Injury Network Causality Assessment: Criteria and Experience in the United States.
Hepatotoxicity due to drugs, herbal or dietary supplements remains largely a clinical diagnosis based on meticulous history taking and exclusion of other causes of liver injury. In 2004, the U.S. Drug-Induced Liver Injury Network (DILIN) was created under the auspices of the U.S. National Institute of Diabetes and Digestive and Kidney Diseases with the aims of establishing a large registry of c...
متن کاملDrug Induced Liver Injury: Can Biomarkers Assist RUCAM in Causality Assessment?
Drug induced liver injury (DILI) is a potentially serious adverse reaction in a few susceptible individuals under therapy by various drugs. Health care professionals facing DILI are confronted with a wealth of drug-unrelated liver diseases with high incidence and prevalence rates, which can confound the DILI diagnosis. Searching for alternative causes is a key element of RUCAM (Roussel Uclaf Ca...
متن کاملReliability of causality assessment for drug, herbal and dietary supplement hepatotoxicity in the Drug-Induced Liver Injury Network (DILIN).
BACKGROUND & AIMS Because of the lack of objective tests to diagnose drug-induced liver injury (DILI), causality assessment is a matter of debate. Expert opinion is often used in research and industry, but its test-retest reliability is unknown. To determine the test-retest reliability of the expert opinion process used by the Drug-Induced Liver Injury Network (DILIN). METHODS Three DILIN hep...
متن کاملCBR: Strengths and Weaknesses
There is considerable enthusiasm about Case-Based Reasoning as a means of developing knowledge-based systems. There are two broad reasons for this enthusiasm. First, it is evident that much of human expert competence is experience based and it makes sense to adopt a reuse-based methodology for developing knowledge based systems. The other reason is the expectation that using Case-Based Reasonin...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2011
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2011.02.007